论文摘要
The catalytic radical-initiated asymmetric 1,2-aminosilylation of alkene with a hydrosilane under Cu（I）/CPA cooperative catalysis has been developed. This method features the use of hydrosilane as the reductive radical precursor, enabling efficient access to skeletally diverse silicon-containing azaheterocycles including pyrrolidine, indoline and isoindoline bearing an α-tertiary stereocenter with high enantioselectivity. The key to the success includes the use of Cu（I）/CPA cooperative catalyst system and the β-silicon effect of the silyl group to stabilize the in situ generated carbocation intermediate.
论文目录
文章来源
类型: 期刊论文
作者: Yang Zeng,Xiao-Dong Liu,Xian-Qi Guo,Qiang-Shuai Gu,Zhong-Liang Li,Xiao-Yong Chang,Xin-Yuan Liu
来源: Science China(Chemistry) 2019年11期
年度: 2019
分类: 工程科技Ⅰ辑
专业: 化学
单位: Shenzhen Grubbs Institute, Southern University of Science and Technology,Department of Chemistry, Southern University of Science and Technology,Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology
基金: supported by the National Natural Science Foundation of China(21722203,21831002,21801116,21572096),Shenzhen Special Funds for the Development of Biomedicine,Internet,New Energy,and New Material Industries(JCYJ20170412152435366,JCYJ20170307105638498,JCYJ20180302180235837),Guangdong Natural Science Foundation(2018A030310083),Shenzhen Nobel Prize Scientists Laboratory Project(C17783101)
分类号: O621.251
页码: 1529-1536
总页数: 8
文件大小: 657K
下载量: 5