论文摘要
Chromatin modifications play important roles in eukaryotic gene regulation. Polycomb repressive complex 2（PRC2） catalyzes repressive histone 3 lysine-27 trimethylation（H3K27me3） to mediate genome-wide transcriptional repression in plants and animals. PRC2 controls various developmental processes in plants and plays a critical role in the developmental transition to flowering. FLOWERING LOCUS C（FLC）, first identified in Arabidopsis thaliana, is a potent floral repressor in crucifers and some other plants, and is subjected to complex regulation in response to endogenous signals（developmental state and hormones） and environmental inputs such as winter cold. In a genetic screening for PRC2 partners in Arabidopsis, we identified HISTONE DEACETYLASE 9（HDA9） to be required for PRC2 function and further found that HDA9-mediated H3K27 deacetylation is required for PRC2-mediated H3K27 trimethylation in the Arabidopsis genome. Moreover, we found that through physical association with the epigenome readers VP1/ABI3-LIKE 1（VAL1） and VAL2 that bind to a cis-regulatory DNA element at the FLC locus, HDA9 and PRC2 function in concert to mediate H3K27 deacetylation and subsequent trimethylation at this residue, leading to FLC repression in the rapid-cycling or early flowering Arabidopsis accessions. Together, our findings uncover a previously-undescribed role of HDA9 in PRC2-mediated H3K27me3 and for FLC repression and flowering-time regulation.
论文目录
文章来源
类型: 国内会议
作者: Xiaolin Zeng,Zheng Gao,Yuehui He
来源: 第三届全国植物开花·衰老与采后生物学大会 2019-11-04
年度: 2019
分类: 基础科学
专业: 生物学,生物学
单位: Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Mol ecular Plant Sciences, Chinese Academy of Sciences(CAS)
分类号: Q943.2
DOI: 10.26914/c.cnkihy.2019.003323
页码: 37
总页数: 1
文件大小: 516k
下载量: 20