Preparation and Spectroscopic of Vanadyl(Ⅱ) Vitamin D3 Amino Acid Mixed Complexes as Insulin Mimetic Drug

Preparation and Spectroscopic of Vanadyl(Ⅱ) Vitamin D3 Amino Acid Mixed Complexes as Insulin Mimetic Drug

论文摘要

A new six intraperitoneal injection insulin-mimetic vanadyl(Ⅱ) compounds [(VD■)(VO+2)(AA-1n)](where(n=1~6); AA1=isoleucine, AA2=threonine, AA3=proline, AA4=phenylalanine, AA5=lysine and AA6=glutamine) were synthesized by the chemical reactions between vitamin D3(VD3), VOSO4 and amino acids(AAn) with equal molar ratio 1∶1∶1 in neutralized media. The structures of these complexes were elucidated by spectroscopic methods like, infrared and solid reflectance spectroscopes. Magnetic moments and electronic spectra reveal square pyramid geometrical structure of the complexes. The infrared spectra assignments of these complexes revealed that the chelation towards vanadyl(Ⅳ) ions existed via deprotonation of the hydroxyl group of VD3 drug ligand and so amino acids act as bidentate ligand via N-amino and O-carboxylate groups. The anti-diabetic efficiency of these complexes were evaluated against streptozotocin induced diabetic male albino rats.

论文目录

  • Introduction
  • 1 Experimental
  •   1.1 Chemical and reagents
  •   1.2 Synthesis of vanadyl (Ⅳ) -vitamin D3-amino acid complexes
  •   1.3 Instruments
  •   1.4 Experimental animals design
  •   1.5 Induction of experimental diabetes
  • 2 Results and discussion
  •   2.1 Interpretations of the chemical structure
  •   2.2 Biological investigation of vanadyl (Ⅳ) complexes on diabetic rats
  • 文章来源

    类型: 期刊论文

    作者: Enas Aljuhani,Amnah M. A. Alsuhaibani,A. M. El-Didamony,N. Hassan,Sameh Abo Taleb,Moamen S. Refat

    来源: 光谱学与光谱分析 2019年07期

    年度: 2019

    分类: 基础科学,工程科技Ⅰ辑,医药卫生科技

    专业: 有机化工,药学

    单位: Department of Chemistry,Faculty of Applied Science,Umm Al-Qura University,Nutrition and Food Sciences Dept.,Home Economic College,Princess Nourah Bint Abdulrahman University,Department of Chemistry,Faculty of Science,Zagazig University,Department of Chemistry,Faculty of Science,Port Said,Port Said University,Chemistry Department,Faculty of Science,Taif University

    分类号: R943

    页码: 2316-2324

    总页数: 9

    文件大小: 872K

    下载量: 16

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    Preparation and Spectroscopic of Vanadyl(Ⅱ) Vitamin D3 Amino Acid Mixed Complexes as Insulin Mimetic Drug
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