TGFβ1-Smad信号通路在胆管癌中作用的研究现状

论文摘要

转化生长因子β1（TGFβ1）-Smad信号通路是胆管癌发展、侵袭及远处转移过程中的重要因子。TGFβ1-Smad信号通路在细胞上皮间-质转化（epithelial-mesenchymal transition,EMT）中也起到至关重要的作用,可使细胞间的黏附性降低,肿瘤细胞能透过基底膜,广泛侵袭至癌旁组织,并发生远处转移。故TGFβ1-Smad信号通路在胆管癌发展中作用的研究是胆管癌相关研究中的焦点所在。本文就近几年TGFβ1-Smad信号通路与胆管癌的关系相关研究进展做综述。

论文目录

文章来源

类型: 期刊论文

作者: 赵宇青,国麟祺,何其勇

关键词: 胆管癌,上皮间质转化,信号通路

来源: 黑龙江医学 2019年12期

年度: 2019

分类: 医药卫生科技

专业: 肿瘤学

单位: 佳木斯大学附属第一医院

分类号: R735.8

页码: 1547-1548

总页数: 2

文件大小: 1805K

下载量: 91

相关论文文献

• [1].Regulatory Effect of Shenge Yifei Capsule on TGF-β1/Smad Signaling Pathway in Rats with Chronic Obstructive Pulmonary Disease[J]. Medicinal Plant 2020(01)
• [2].Linggui Zhugan Decoction(苓桂术甘汤) Inhibits Ventricular Remodeling after Acute Myocardial Infarction in Rats by Suppressing TGF-β1/Smad Signaling Pathway[J]. Chinese Journal of Integrative Medicine 2020(05)
• [3].TGFβ/Smad信号通路在口腔鳞癌热疗中的表达变化[J]. 实用口腔医学杂志 2019(01)
• [4].Wulong Xiaozheng Wan medicated serum inhibits epithelial-mesenchymal transition in human gastric carcinoma cell line BGC823 by modulation of transforming growth factor-β_1/Smad signaling[J]. Journal of Traditional Chinese Medicine 2019(03)
• [5].Involvement of Rho-associated coiled-coil kinase signaling inhibition in TGF-β1/Smad2,3 signal transduction in vitro[J]. International Journal of Ophthalmology 2017(12)
• [6].The Analysis of Relationship between MSTN/Smad Signal Path and Turpan Black Sheep Meat Production[J]. Agricultural Science & Technology 2016(01)
• [7].Association of Down-regulation of CD109 Expression with Up-expression of Smad7 in Pathogenesis of Psoriasis[J]. Journal of Huazhong University of Science and Technology(Medical Sciences) 2016(01)
• [8].脑星形细胞瘤组织TGF-β1、Smad7与VEGF的表达及意义[J]. 健康之路 2016(12)
• [9].Qingxuan Jiangya Decoction(清眩降压汤) Prevents Blood Pressure Elevation and Ameliorates Vascular Structural Remodeling via Modulating TGF-β 1/Smad Pathway in Spontaneously Hypertensive Rats[J]. Chinese Journal of Integrative Medicine 2020(03)
• [10].Early intervention with Di-Dang Decoction prevents macrovascular fibrosis in diabetic rats by regulating the TGF-β1/Smad signalling pathway[J]. Chinese Journal of Natural Medicines 2020(08)
• [11].Naringenin prevents experimental liver fibrosis by blocking TGFβ-Smad3 and JNK-Smad3 pathways[J]. World Journal of Gastroenterology 2017(24)
• [12].Anterior segment dysgenesis correlation with epithelial-mesenchymal transition in Smad4 knockout mice[J]. International Journal of Ophthalmology 2016(07)
• [13].Effect of bone marrow mesenchymal stem cells on the Smad expression of hepatic fibrosis rats[J]. Asian Pacific Journal of Tropical Medicine 2014(04)
• [14].Expression of USP15, TβR-Ⅰand Smad7 in Psoriasis[J]. Journal of Huazhong University of Science and Technology(Medical Sciences) 2014(03)
• [15].Smad蛋白研究进展[J]. 中国医学创新 2013(12)
• [16].Effect of the Protease Inhibitor MG132 on the Transforming Growth Factor-β/Smad Signaling Pathway in HSC-T6 Cells[J]. Journal of Huazhong University of Science and Technology(Medical Sciences) 2013(04)
• [17].Role of Smad7 in inflammatory bowel diseases[J]. World Journal of Gastroenterology 2012(40)
• [18].HSP70 decreases receptor-dependent phosphorylation of Smad2 and blocks TGF-β-induced epithelial-mesenchymal transition[J]. 遗传学报 2011(03)
• [19].Berbamine inhibits proliferation and induces apoptosis of KU812 cells by increasing Smad3 activity[J]. Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011(07)
• [20].Smad信号调控软骨形成机制的研究进展[J]. 国际口腔医学杂志 2010(05)
• [21].Smad7 dependent expression signature highlights BMP2 and HK2 signaling in HSC transdifferentiation[J]. World Journal of Gastroenterology 2010(41)
• [22].Smad蛋白在转化生长因子-β信号转导通路中的作用与机制[J]. 医学分子生物学杂志 2008(04)
• [23].微小RNA-21-5p靶向Smad7调控转化生长因子-β_1诱导心肌纤维化促进房颤的发生[J]. 临床内科杂志 2019(07)
• [24].孕期尼古丁暴露所致子代成骨细胞BMP-4/Smad信号通路的变化[J]. 医学研究杂志 2018(11)
• [25].白细胞介素37/Smad3在兔腹主动脉粥样硬化斑块中的表达研究[J]. 中国心血管杂志 2019(02)
• [26].三步序贯法对激素依赖型哮喘患者TGF-β_1/Smad信号通路及肺功能的影响[J]. 中华中医药杂志 2019(09)
• [27].牦牛bta-miR-1434-5p和Smad1基因组织表达谱及荧光素酶报告载体构建[J]. 中国农业大学学报 2018(05)
• [28].Effect of Banxia Xiexin decoction on Helicobacter pylori-related peptic ulcers and its possible mechanism via the TGF-β/Smad signaling pathway[J]. Journal of Traditional Chinese Medicine 2018(03)
• [29].San-Cao Granule (三草颗粒) Ameliorates Hepatic Fibrosis through High Mobility Group Box-1 Protein/Smad Signaling Pathway[J]. Chinese Journal of Integrative Medicine 2018(07)
• [30].Smad1基因在敖汉细毛羊发情不同时期卵巢中的表达规律研究[J]. 黑龙江畜牧兽医 2017(21)

标签：胆管癌论文;  上皮间质转化论文;  信号通路论文;