Enhanced urease inhibition activity of Ag nanomaterials capped with N-substituted methyl 5-acetamido-β-resorcylate

论文摘要

Medically, bacterial ureases are important virulent factors and are used for treatment of peptic ulcers and urinary tones. Reported urease inhibitors are associated with various side effects including antibiotic resistance as a major one. Still there is an urgent need to synthesize new urease inhibitors. In this context we have synthesized new urease inhibitor i.e. AgL that is composed of Ag nanomaterials capped with N-substituted methyl 5-acetamido-β-resorcylate（L）. The conjugation of L to silver was confirmed through FTIR, UV–vis and TEM analysis.Bare silver nanomaterials（Ag） were also prepared. The stability of AgL nanostructures was determined against various parameters（temperature, high salt concentration, pH） and found to be stable. The in vitro antimicrobial（antibacterial, antifungal）, enzyme inhibition（xanthine oxidase, urease, carbonic anhydrase, α-chymotrypsin,cholinesterase） and antioxidant activities of AgL were investigated and compared with Ag, L and standard drugs.In comparison to other bioactivities, AgL shows statistically enhanced selective enzyme inhibition activity against urease enzyme. Urease inhibition activity of AgL was significantly greater than standard drug（thiourea）,L and Ag. On a per weight basis, AgL required about 11–18 times less amount of L for inhibition of urease enzyme.

论文目录

文章来源

类型: 期刊论文

作者: Syeda Sohaila Naz,Muhammad Raza Shah,Nazar Ul Islam,Syed Sartaj Alam

来源: Progress in Natural Science:Materials International 2019年02期

年度: 2019

分类: 基础科学,工程科技Ⅰ辑,医药卫生科技

专业: 有机化工,材料科学,药学

单位: Nanosciences and Technology Department, National Centre for Physics, Quaid-i-Azam University Campus,ICCBS, H.E.J.Research Institute of Chemistry, University of Karachi,Institute of Chemical Sciences, University of Peshawar,Sarhad University of Science and Information Technology,Department of Plant Pathology, The University of Agriculture,Peshawar, Pakistan

基金: Funding from Higher Education Commission,Pakistan(Case No.074-1987-Ps4-206)

分类号: R943;TB383.1

页码: 129-137

总页数: 9

文件大小: 3953K

下载量: 2

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