Adverse Effect of TiO2 Nanoparticles on Antioxidant System and Antitumor Activities of Macroalgae Gracilaria lemaneiformis

论文摘要

Recently, the widespread use of TiO2nanoparticles（nano-TiO2） has attracted the global concern regarding their adverse effects to aquatic organisms. Nanoparticles may get to the aquatic environments and harm the growth of algae. This paper presents the studies of nano-TiO2 concentrations influence on the photosynthetic characteristics, antioxidant system and antitumor activity of marine macroalgae Gracilaria lemaneiformis after exposed to 0, 5, 10, 20 or 40 mg L-1 of nano-TiO2. Results showed that the photosynthetic pigment content of G. lemaneiformis obviously decreased and the antioxidant defense system was significantly disturbed after exposure to nano-TiO2. Compared with control, the maximum level of malondialdehyde showed 3.3-fold increase for 15 days exposure to nano-TiO2. The activity of superoxide dismutase and catalase enhanced obviously by 1.10-2.24-fold. The aqueous extract of G. lemaneiformis（AEGL） possesses anticancer activity against HepG2 liver cancer cells proliferation and the 48 h-cell inhibition exceeds 35%. But the toxicity of nano-TiO2 would inhibit the anticancer activity of AEGL. When G. lemaneiformis was exposed to nano-TiO2, the effect of the aqueous extract of G. lemaneiformis on the cell inhibition, reactive oxygen species production, apoptosis, cycle arrest of HepG2 cells significantly lessened, and which were linearly associated with nano-TiO2 exposure concentration. Those results further confirmed that nano-TiO2 can inhibit the anticancer activity of G. lemaneiformis. The results in this work imply that macroalgae can be an effective biomarker of nano-TiO2 contaminant, and can be useful indicator to evaluate ecological effects of increasing pollutants in marine ecosystem.

论文目录

文章来源

类型: 期刊论文

作者: LIU Jie,YIN Pinghe,ZHAO Ling

来源: Journal of Ocean University of China 2019年05期

年度: 2019

分类: 基础科学,工程科技Ⅰ辑

专业: 环境科学与资源利用

单位: Department of Chemistry, Jinan University,Research Center of Analysis and Test, Jinan University,Key Laboratory of Water/Soil Toxic Pollutants Control and Bioremediation of Guangdong Higher Education Institutes, Department of Environmental Engineering, Jinan University

基金: supported by the NSFC-Guangdong Province Joint Key Project (No. U1301235),the National Natural Science Foundation of China (No. 41676110),the Industry-University-Research Combination Project of Guangdong Province (No. 2013B090600009),the Science and Technology Program of Guangdong,China (No. 2014A020217007)

分类号: X171.5

页码: 1130-1138

总页数: 9

文件大小: 1238K

下载量: 15

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