Optimizing the Aspect Ratio of Cephalexin in Reactive Crystallization by Controlling Supersaturation and Seeding Policy

论文摘要

Batch crystallization in acidic aqueous solution of cephalexin was conducted by reactive crystallization with or without seeding. Supersaturation was generated by mixing ammonia and acidic aqueous solution of cephalexin and controlled by solution feeding rate and seeding conditions. UV and Morphologi G3 were used to measure supersaturation and aspect ratio. Experimental results demonstrated that burst nucleation occurred and the products were needle-like at high supersaturation; meanwhile, the products were plate-like and had high aspect ratio at low supersaturation. Analysis of the measured supersaturation profiles and corresponding aspect ratio explained the mechanisms governing the aspect ratio. The optimized operating parameters were also proposed（seeding supersaturation is equal to 1.3, seed mass ratio 8% and feeding rate 368 μL/min）.

论文目录

文章来源

类型: 期刊论文

作者: Mingchen Li,Zeren Shang,Baohong Hou

来源: Transactions of Tianjin University 2019年04期

年度: 2019

分类: 工程科技Ⅱ辑,工程科技Ⅰ辑

专业: 无机化工,有机化工,工业通用技术及设备

单位: School of Chemical Engineering and Technology,State Key Laboratory of Chemical Engineering,Tianjin University,Collaborative Innovation Center of Chemical Science and Engineering of Tianjin,Tianjin University

基金: supported by the Major National Science and Technology Projects (No. 2017ZX07402003),Major National Scientifi c Instrument Development Project (No. 21527812)

分类号: TQ465.1;TQ026.5

页码: 348-356

总页数: 9

文件大小: 3422K

下载量: 4

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