论文摘要
Nanoparticles are considered to be a powerful approach for the delivery of poorly watersoluble drugs. One of the main challenges is developing an appropriate method for preparation of drug nanoparticles. As a simple, rapid and scalable method, the flash nanoprecipitation（FNP） has been widely used to fabricate these drug nanoparticles, including pure drug nanocrystals, polymeric micelles,polymeric nanoparticles, solid lipid nanoparticles, and polyelectrolyte complexes. This review introduces the application of FNP to produce poorly water-soluble drug nanoparticles by controllable mixing devices, such as confined impinging jets mixer（CIJM）, multi-inlet vortex mixer（MIVM） and many other microfluidic mixer systems. The formation mechanisms and processes of drug nanoparticles by FNP are described in detail. Then, the controlling of supersaturation level and mixing rate during the FNP process to tailor the ultrafine drug nanoparticles as well as the influence of drugs, solvent, anti-solvent, stabilizers and temperature on the fabrication are discussed. The ultrafine and uniform nanoparticles of poorly watersoluble drug nanoparticles prepared by CIJM, MIVM and microfluidic mixer systems are reviewed briefly. We believe that the application of microfluidic mixing devices in laboratory with continuous process control and good reproducibility will be benefit for industrial formulation scale-up.
论文目录
文章来源
类型: 期刊论文
作者: Jinsong Tao,Shing Fung Chow,Ying Zheng
来源: Acta Pharmaceutica Sinica B 2019年01期
年度: 2019
分类: 医药卫生科技,工程科技Ⅰ辑
专业: 有机化工,药学
单位: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Science, University of Macau,Department of Pharmacology and Pharmacy, The University of Hong Kong
基金: supported by Research Committee of University of Macau (MYRG2017-00200-ICMS),Macao Science and Technology Development Fund (FDCT 0013,2018,A1)
分类号: R943
页码: 4-18
总页数: 15
文件大小: 358K
下载量: 42