芪地糖肾颗粒对糖尿病肾病大鼠肾组织TGF-β1-Smad2/3信号通路的影响

论文摘要

目的观察芪地糖肾颗粒对糖尿病肾病（diabetic nephropathy, DN）大鼠肾组织内转换生长因子（TGF）-β1-Smad2/3信号通路的影响。方法采用单侧腹腔注射链脲佐菌素（streptozotocin, STZ）制备DN大鼠模型,并用中药芪地糖肾颗粒干预。ELISA法检测24 h尿微量白蛋白（microalbuminuria, MAU）水平,光学显微镜观察大鼠肾脏结构,Western Blot检测大鼠肾组织TGF-β1、smad2、smad3、a-SMA蛋白表达。结果中药芪地糖肾颗粒干预后,大鼠24 hMAU水平下降（P<0.01）;肾组织内 TGF-β1表达水平降低（P<0.01）;光镜下模型组大鼠肾小球系膜基质增多、毛细血管基底膜增厚,肾小管上皮细胞肥大扩张,呈空格样改变,中药干预后肾小管病变程度降低。结论芪地糖肾颗粒通过TGF-β1-smad2/3通路下调TGF-β1的表达水平来防治糖尿病肾病的纤维化。

论文目录

文章来源

类型: 期刊论文

作者: 何其英,柳红芳

关键词: 糖尿病肾病,芪地糖肾颗

来源: 长春中医药大学学报 2019年06期

年度: 2019

分类: 医药卫生科技

专业: 中药学

单位: 北京中医药大学东直门医院

基金: G20工程支撑保障项目(Z161100001816003)

分类号: R285.5

DOI: 10.13463/j.cnki.cczyy.2019.06.032

页码: 1125-1128

总页数: 4

文件大小: 1463K

下载量: 165

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标签：糖尿病肾病论文;  芪地糖肾颗论文;