导读:本文包含了正丙基硫脲嘧啶论文开题报告文献综述、选题提纲参考文献及外文文献翻译，主要关键词:硫脲,嘧啶,丙基,甲状腺,卵巢,时效,银屑病。
正丙基硫脲嘧啶论文文献综述
陈浩,张晓鹏,李谦,苏卿,贾旭东[1]（2014）在《丙基硫脲嘧啶对去卵巢大鼠甲状腺干扰作用的时效关系研究》一文中研究指出目的研究丙基硫脲嘧啶(PTU)对甲状腺干扰作用的敏感指标及其时间效应模式。方法去卵巢大鼠随机分为3个给药组,分别给予5 mg/kg BW的PTU连续灌胃4、8和12 d,同时设手术对照组和假手术对照组,灌胃给予玉米油。测定指标包括血清T3、T4和TSH,肝脏I型5'-脱碘酶和苹果酸酶活性,甲状腺组织病理学改变以及表皮胶质比。结果与手术对照组相比,给药各组血清T3均降低(P<0.05),TSH均升高(P<0.05)。与手术对照组相比,4 d组血清T4差异无统计学意义(P>0.05),而8和12 d组T4降低(P<0.05)。血清T3和T4随给药时间增加而下降,血清TSH则随时间增加而升高。同手术对照组相比,给药各组Ⅰ型5'-脱碘酶活性均降低(P<0.05),苹果酸酶活性差异无统计学意义(P>0.05)。给药各组甲状腺滤泡间可见毛细血管充血,滤泡上皮不同程度增生,胶质减少,表皮胶质比均升高(P<0.05)。结论血清甲状腺激素T3、T4和TSH,I型5'-脱碘酶活性,甲状腺表皮胶质比及病理学改变可作为评价甲状腺干扰作用的敏感指标;PTU干扰去卵巢大鼠的甲状腺功能存在明显的时效关系,给药8 d是最敏感观察期。(本文来源于《中国食品卫生杂志》期刊2014年01期）
EliasA,N,Barr,R,J[2]（2005）在《用丙基硫脲嘧啶,治疗银屑病后皮肤表达p16的研究》一文中研究指出Plaque formation is a characteristic finding in patients with psoriasis and re flects cytokine-induced keratinocyte proliferation and/or impaired apoptosis of keratinocytes. Antithyroid thioureylenes such as propylthiouracil (PTU) and met himazole (MMI) are effective in the treatment of plaque psoriasis. Following PTU and MMI treatment, proliferative cell nuclear antigen (PCNA) expression is sign ificantly reduced, suggesting that these medications have an antiproliferative effect. p 16 is an antiapoptotic protein that is present in relative abundance in psoriati c plaques and is believed to play a potential role in the persistent senescence and impaired apoptosis of the keratinocytes in the plaque. This study examined p 16 expression in biopsy samples of eight patients with plaque psoriasis given 30 0 mg of propylthiouracil in divided doses for 3 months. Despite significant clin ical and histological improvement with PTUtreatment,p16expressionwasessentiallyu nchanged,suggesting that the beneficial effect of PTU in psoriasis is not mediat ed through a decrease in p16 expression. The effect of PTU on other antiapoptoti c proteins such as bcl-xL remains to be determined.(本文来源于《世界核心医学期刊文摘(皮肤病学分册)》期刊2005年05期）
正丙基硫脲嘧啶论文开题报告
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Plaque formation is a characteristic finding in patients with psoriasis and re flects cytokine-induced keratinocyte proliferation and/or impaired apoptosis of keratinocytes. Antithyroid thioureylenes such as propylthiouracil (PTU) and met himazole (MMI) are effective in the treatment of plaque psoriasis. Following PTU and MMI treatment, proliferative cell nuclear antigen (PCNA) expression is sign ificantly reduced, suggesting that these medications have an antiproliferative effect. p 16 is an antiapoptotic protein that is present in relative abundance in psoriati c plaques and is believed to play a potential role in the persistent senescence and impaired apoptosis of the keratinocytes in the plaque. This study examined p 16 expression in biopsy samples of eight patients with plaque psoriasis given 30 0 mg of propylthiouracil in divided doses for 3 months. Despite significant clin ical and histological improvement with PTUtreatment,p16expressionwasessentiallyu nchanged,suggesting that the beneficial effect of PTU in psoriasis is not mediat ed through a decrease in p16 expression. The effect of PTU on other antiapoptoti c proteins such as bcl-xL remains to be determined.
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正丙基硫脲嘧啶论文参考文献
[1].陈浩,张晓鹏,李谦,苏卿,贾旭东.丙基硫脲嘧啶对去卵巢大鼠甲状腺干扰作用的时效关系研究[J].中国食品卫生杂志.2014
[2].EliasA,N,Barr,R,J.用丙基硫脲嘧啶,治疗银屑病后皮肤表达p16的研究[J].世界核心医学期刊文摘(皮肤病学分册).2005