论文摘要
Two Cu（Ⅱ） complexes of [Cu（2,6-DPC）（Hnta）（H2O）]·H2O（2,6-DPC = 2,6-pyridinedicarboxylic-carboxylate, Hnta = nicotinic acid） and [Cu2（2,4-D）4（Hnta）2]（2,4-D = 2,4-dichlorophenoxyacetic-carboxylate） were synthesized and successfully obtained as single crystals in this paper. The supramolecular structures of the complexes from zero to three dimensions and the weak intermolecular force in the crystal were analyzed. The single-crystal structures of the complexes were further analyzed by Hirshfeld surface analysis. The competition capacity of the complexes about calf thymus DNA（ct-DNA） was also analyzed by fluorescence spectroscopy. The ability of complexes to cleave the plasmid DNA（pBR322-DNA） was determined by gel electrophoresis assay. And at last, the complexes’ cytotoxic activities were reviewed for four kinds of cancer cell lines（HeLa, MCF-7, HepG, SKOV-3）, showing that the coordination polymer has anti-tumor activity and cytotoxicity.
论文目录
文章来源
类型: 期刊论文
作者: 王仁舒,冯静,连明磊,孔德顺,雷以柱,石开仪
来源: Chinese Journal of Structural Chemistry 2019年08期
年度: 2019
分类: 工程科技Ⅰ辑
专业: 化学
单位: School of Chemistry and Materials Engineering, Liupanshui Normal University
基金: Supported by the Guizhou Provincial Science and Technology Foundation(No.LKLS[2013]20),the Scientific and Technological Innovation Platform of Liupanshui(52020-2018-02-01 and 52020-2017-02-02),Youth Talent Growth Project of Educational Department of Guizhou Province(No.KY [2017]271),2011 Collaborative Innovation Center of Guizhou Province(Qian Jiao he xietongchuangxin zi [2016]02)
分类号: O641.4
DOI: 10.14102/j.cnki.0254-5861.2011-2252
页码: 1297-1310
总页数: 14
文件大小: 1489K
下载量: 17