Specific and stable suppression of hepatitis B virus expression by DNA methyltransferase1 and methyltransferase3a via specific zinc-finger-induced methylation of the X promoter

论文摘要

<正>Background: Hepatitis B virus（HBV）infection is a chronic liver disease resulting in hepatocellular carcinoma. Current therapies fail to provide effective long-term control of viral replication in patients. DNA methylation is a potential therapeutic approach to suppress DNA replication. Our previous study established a fusion protein integrating a C-terminal Zinc-finger domain of Dnmt3 a and Dnmt1 that

论文目录

文章来源

类型: 国际会议

作者: Li X.,Zhu S.,Zhu N.

来源: 第十七届国际免疫学大会 2019-10-19

年度: 2019

分类: 基础科学,医药卫生科技

专业: 生物学,基础医学

单位: Fudan University

分类号: R373.2

DOI: 10.26914/c.cnkihy.2019.003065

页码: 114

总页数: 1

文件大小: 291k

下载量: 3

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