Although active constituents extracted from plants show robust in vitro pharmacological effects, low in vivo absorption greatly limits the widespread application of these compounds. A strategy of using phyto-phospholipid complexes represents a promising approach to increase the oral bioavailability of active constituents, which is consist of ‘‘label-friendly"phospholipids and active constituents. Hydrogen bond interactions between active constituents and phospholipids enable phospholipid complexes as an integral part. This review provides an update on four important issues related to phyto-phospholipid complexes: active constituents, phospholipids, solvents, and stoichiometric ratios. We also discuss recent progress in research on the preparation, characterization, structural verification, and increased bioavailability of phyto-phospholipid complexes.
类型: 期刊论文
作者: Mei Lu,Qiujun Qiu,Xiang Luo,Xinrong Liu,Jing Sun,Cunyang Wang,Xiangyun Lin,Yihui Deng,Yanzhi Song
来源: Asian Journal of Pharmaceutical Sciences 2019年03期
年度: 2019
分类: 医药卫生科技,工程科技Ⅰ辑
专业: 有机化工,药学
单位: College of Pharmacy, Shenyang Pharmaceutical University,College of Pharmaceutical Engineering, Shenyang Pharmaceutical University
分类号: R943
页码: 265-274
总页数: 10
文件大小: 400K
下载量: 10
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