Although surgical resection and chemotherapy were widely applied in tumor therapy, the dysfunction of normal cells resulted in the side effects （such as anorexia, nausea）. MW thermal therapy is a non-invasive anticancer strategy under the help of MW sensitizer, with the safety and higher efficacy. Zirconium metal-organic framework nanocubes （ZrMOF NCs） modified with polyethylene glycol, were prepared via one pot method and carbodiimide technique, resulting in their large specific surface area and porosity.Our results showed that non-ion-loaded ZrMOF NCs in 0.9% NaCl solution exhibited better heating effect,higher than that in pure water, due to the robust collision among the ions under MW irradiation. The in vivo experiments confirmed that ZrMOF-PEG NCs + MW group exhibited the higher temperature in the tumor region than that of only MW treatment, suggesting a better MW thermal therapeutic anticancer efficacy. This work provides a new preparation strategy of biosafety nanomaterial as MW sensitizer for enhancing MW thermal anticancer therapy.
类型: 期刊论文
作者: Yuanwen Zou,Wei Zhang,Hongqiao Zhou,Changhui Fu,Longfei Tan,Zhongbing Huang,Xiangling Ren,Jun Ren,Xudong Chen,Xianwei Meng
来源: Chinese Chemical Letters 2019年02期
年度: 2019
分类: 工程科技Ⅰ辑
专业: 有机化工,材料科学
单位: College of Materials Science and Engineering, Sichuan University,Second Clinical Medical College of Jinan University, Shenzhen People's Hospital,Laboratory of Controllable Preparation and Application of Nanomaterials CAS Key Laboratory of Cryogenics Technical Institute of Physics and Chemistry Chinese Academy of Sciences (CAS)
基金: financial support from the National Science Foundation of China(Nos. 61671435 and 81630053),Beijing Natural Science Foundation(No. 4161003)
分类号: TQ460.1;TB383.1
页码: 481-484
总页数: 4
文件大小: 782K
下载量: 15
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