Over the past few decades, the usage of oxytetracycline（OTC）, a kind of antibiotic, has increased with the development of aquaculture and livestock breeding. However, about 30–90% of the applied antibiotics are excreted as the parent compounds into the environment, especially with the application of animal manure to agricultural fields. This large influx of antibiotics may lead to the destruction of the natural microbial ecological community and pose great threats to human beings through the food chain. Therefore, the fate and toxicity of OTC in the environment are issues of great concern. Degradation of OTC, including the non-biodegradation and biodegradation, and the biological toxicity of its degradation products or metabolites, are reviewed in this paper. The non-biodegradation pathways include hydroxylation, quinonization, demethylation, decarbonylation, dehydration and secondary alcohol oxidation. Light（particularly UV light）, pH and oxidizing substances play important roles in non-biodegradation. Biodegradation products include 4-epi-OTC（EOTC）, 2-acetyl-2-decarboxy-amido-OTC（ADOTC）, α-apo-OTC and β-apo-OTC. EOTC is an epimer and identied except for the configuration of the C4 dimethylamino group of OTC. Temperature and pH are the main factors affecting biodegradation pathways of OTC. In addition, this review discusses concerns over the biological toxicity of OTC degradation products.
类型: 期刊论文
作者: LI Zhao-jun,QI Wei-ning,FENG Yao,LIU Yuan-wang,Ebrahim Shehata,LONG Jian
来源: Journal of Integrative Agriculture 2019年09期
年度: 2019
分类: 农业科技,工程科技Ⅰ辑
专业: 环境科学与资源利用
单位: Key Laboratory of Plant Nutrition and Fertilizer, Ministry of Agriculture and Rural Affairs/China-New Zealand Joint Laboratory for Soil Molecular Ecology, Institute of Agricultural Resources and Regional Planning, Chinese Academy of Agricultural Sciences,Guizhou Key Laboratory of Mountain Environment, Guizhou Normal University
基金: supported by the National Key R&D Program of China (2018YFD0500206),the National Natural Science Foundation of China (31772395),the Fundamental Research Funds for Central Non-profit Scientific Institution of Institute of Agricultural Resources and Regional Planning,Chinese Academy of Agricultural Sciences (IARRP-2017-13)
分类号: X50
页码: 1953-1960
总页数: 8
文件大小: 589K
下载量: 14
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