Inadequate strength at the bone/cement interface is one of the main drawbacks of poly（methylmethacrylate）（PMMA）bone cement in the current orthopedic surgeries.In the present work,a partially degradable PMMA/Mg composite bone cement（PMC）was developed for enhancing the bone/cement interfacial strength,which is proposed to be accomplished by increasing the osteo-conductivity of PMMA and enhancing the mechanical interlocking between bone tissue and the porous PMMA surface formed by the degradation of Mg on the surface of the cement.PMCs were prepared with various concentrations of Mg particles with different sizes and alloy compositions.The effects of Mg particle size,composition and content on the injectability,mechanical and degradation properties,and biocompatibility of PMCs were evaluated.The results show that these parameters affected the properties of the PMCs simultaneously.The good injectability and compressive strengths of PMMA were preserved,while the compatibility to osteoblasts was enhanced when adding Mg particles in a proper manner.The PMCs degraded at the surface with time and formed porous surface structures in the physiological environment,while maintaining the original compressive strengths.This preliminary study shows that the PMC is promising for minimally invasive orthopedic surgery;however,it still requires to be optimized and evaluated in the future.
类型: 期刊论文
作者: Xiao Lin,Adrian Chan,Xiao-Xiao Tan,Hui-Lin Yang,Lei Yang
来源: Acta Metallurgica Sinica(English Letters) 2019年07期
年度: 2019
分类: 工程科技Ⅰ辑,医药卫生科技
专业: 材料科学,生物医学工程
单位: Orthopaedic Institute, Soochow University,Department of Orthopaedics, The First Affiliated Hospital of Soochow University,Waterloo Institute for Nanotechnology (WIN), University of Waterloo,School of Materials Engineering, Shanghai University of Science and Engineering
基金: supported by the National Natural Science Foundation of China (Nos. 81501858,81622032,51501109 and 51672184),the Principal Project of Natural Science Research of Jiangsu Higher Education Institutions (No. 17KJA180011),Jiangsu Innovation and Entrepreneurship Program,the Priority Academic Program Development of Jiangsu High Education Institutions (PAPD)
分类号: TB33;R318.08
页码: 808-816
总页数: 9
文件大小: 6499K
下载量: 3
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