Interferon gene stimulator（STING） is an important immune-related protein located in the endoplasmic reticulum（ER） of mammalian cells. Although STING has been elucidated as a key molecule involved in anti-DNA virus infection in the cells, recent studies showed that STING also plays an important role in restricting RNA virus in cells, but the mechanism beyond remains unclear. Foot-and-mouth disease virus（FMDV） is a single-stranded positive-stranded RNA virus, which causes foot-and-mouth disease in cloven-hoofed animals. Our studies showed that FMDV infection resulted in degradation of STING in PK15 cells and induced cellular autophagy via activating ER stress response. In further exploring how FMDV initiates the signaling cascades, it was found that FMDV induced ER stress responses originates from cellular pattern recognition receptor RIG-I, which transmits signals to the ER anchored adaptor protein STING to specifically activate PERK-EIF2 alpha signaling pathway, and finally leads to autophagy and degradation of STING itself and then resolve ER stress. Knockdown of STING suppressed FMDV replication, but had little effect on the IFN I response. The results illustrated the signaling cascades that mediates cellular stress response to FMDV and uncovered the link between innate immune responses and cellular stress responses.
类型: 国际会议
作者: Zhang R.,Qin X.,Zhang Z.,Zhang Z.
来源: 第十七届国际免疫学大会 2019-10-19
年度: 2019
分类: 基础科学,农业科技
专业: 生物学,畜牧与动物医学
单位: LanZhou Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Viral Diseases in Grazing Animal Team
分类号: S852.65
DOI: 10.26914/c.cnkihy.2019.003000
页码: 80
总页数: 1
文件大小: 254k
下载量: 2
本文来源: https://www.lunwen66.cn/article/c762b5366a89db5b749ea143.html