A reversed phase （RP）/hydrophilic interaction （HILIC）/ion exchange （IEX） mixed tri-mode stationary phase （TMSP） has been prepared via a divergent synthesis scheme starting from propylamine on silica then by amine-epoxy reactions with 1,4-butanedioldiglycidyl ether and tertiary amines （N,Ndimethyldecylamine, DMDA）. Its retention mechanism was found to follow RP/HILIC/IEX mixed-mode.The stop-flow test revealed that TMSP had good compatibility with 100% aqueous mobile phase. It demonstrated effective separation towards several kinds of compounds or drug molecules and their counterions within a single run.
类型: 期刊论文
作者: Sainan Zhang,Feifang Zhang,Bingcheng Yang,Xinmiao Liang
来源: Chinese Chemical Letters 2019年02期
年度: 2019
分类: 工程科技Ⅰ辑
专业: 化学,有机化工
单位: Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology
基金: financially supported by the National Natural Science Foundation of China(Nos. 21477037,21322502),the Outstanding Young Talent Cultivation Fund of East China University of Science and Technology
分类号: O652.6;TQ460.1
页码: 470-472
总页数: 3
文件大小: 592K
下载量: 14
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